Does NAD+ Actually Make A Difference? What I Learned

I’ve always worried about aging — not just in terms of appearance but also in how I feel every day. Low energy, brain fog, and sluggish post-workout recovery is now part of my daily life. I knew I needed to take proactive steps, but traditional healthcare doesn’t offer much beyond OTC vitamins and lifestyle tips. That’s when I discovered AgelessRx, which offers a science-backed, holistic care approach to cellular health, and longevity. 

After my online consultation, my physician at AgelessRx recommended I try their NAD+ injections. Within weeks, I noticed a dramatic improvement in my energy levels, mental clarity, and overall well-being. My workouts flow more easily, I’m more consistent and continuously beating my “personal bests”, and I wake up feeling refreshed instead of drained. AgelessRx is unlike anything I’ve tried before. The accessibility of their telehealth platform makes it simple to receive treatments at home, with no compromise on quality.

Curious to understand why NAD+ has made such a difference, I spoke with Girish Harinath — Science Communications Specialist for AgelessRx — to get a clearer picture of how it works and why it’s redefining the field of longevity. 

Read what Harinath has to say below, or skip to:

• Meet the Expert: Girish Harinath
• What is NAD+ And Why is NAD+ important for the body?
• Why do NAD+ levels decline with age?
• What are the benefits of increasing NAD+?
• What is the difference between NR and NMN in raising NAD+?
• What are the differences between AgelessRx’s NAD+ injections, patches, nasal sprays, and face creams?
• Is NAD+ supplementation safe? Can too much NAD+ be harmful?
• My Final Verdict On Ageless Rx And NAD+
  

Meet the Expert: Girish Harinath

Girish Harinath is a molecular biologist and neuroscientist by training, with a Master of Business and Science in Biotechnology and Genomics. He brings over 12 years of experience studying the biology of aging, with a focus on translating longevity science into real-world health solutions that support both lifespan and healthspan.

Throughout his career, Harinath has worked across multiple areas in the longevity space — including cancer research, biotech, advocacy, investor relations, science communication, and longevity education. At AgelessRx, he plays a key role in translating cutting-edge longevity research into actionable insights and health solutions.

What is NAD+ And Why is NAD+ important for the body?

“NAD+ (Nicotinamide Adenine Dinucleotide) is a vital molecule that fuels over 500 metabolic reactions, powering cellular metabolism, energy production, and DNA repair. It also regulates inflammation, immune health, and circadian rhythm. As NAD+ levels decline with age, these essential functions weaken, contributing to fatigue, cognitive decline, and increased risk of age-related diseases. By supporting cellular health, NAD+ helps keep metabolism efficient and fights damage before it leads to serious health concerns.”

Why do NAD+ levels decline with age?

“As we age, our demand for NAD+ exceeds our body’s ability to produce it. Several factors contribute to this decline:

• Increased NAD+ consumption: Cellular damage, chronic inflammation, and DNA repair processes deplete NAD+ stores.
• Decreased NAD+ biosynthesis (or production): As we age our cell’s ability to turn NAD+ precursors into NAD+ declines (also another direct hit against precursors).
• Inefficient recycling: Used NAD+ is broken down and recycled less effectively as we age.
• External stressors: Poor lifestyle habits, metabolic stress, and environmental toxins further accelerate NAD+ depletion.”

What are the benefits of increasing NAD+?

“Boosting NAD+ levels has been shown to improve:

• Metabolic health
• Physical energy, function, and recovery
• Mental clarity and cognitive function
• Inflammation reduction
• Mood and emotional well-being
• Cellular resilience and long-term health

Clinical trials have demonstrated that NAD+ supplementation can improve sleep quality, reduce inflammatory markers, enhance cardiovascular health, and even support neuroprotection in conditions like Parkinson’s disease.”

What is the difference between NR and NMN in raising NAD+?

“NR (Nicotinamide Riboside) and NMN (Nicotinamide Mononucleotide) are precursors that help boost NAD+ levels. However, studies show they are broken down into nicotinamide (NAM) in the gut before absorption, meaning their effects are similar to NAM despite being more expensive. Direct NAD+ delivery through injections, patches, or nasal sprays bypasses this conversion process and provides more targeted benefits.”

What are the differences between AgelessRx’s NAD+ injections, patches, nasal sprays, and face creams?

“Each delivery method offers unique benefits depending on its target area:

• NAD+ Injections & Patches: Delivered into the bloodstream for full-body effects, enhancing physical energy and reducing inflammation.
• NAD+ Nasal Spray: Directly absorbed into the brain, improving cognitive function, focus, and mental clarity.
• NAD+ Face Cream: Penetrates skin cells to enhance mitochondrial function, reduce oxidative stress, and combat visible signs of aging.”

Is NAD+ supplementation safe? Can too much NAD+ be harmful?

“NAD+ supplementation is safe, as it is a naturally occurring molecule in every cell of the body, with a safety profile similar to vitamins. Clinical trials with doses between 500 mg and 2 g have shown no serious side effects, only mild discomfort like flushing or temporary digestive issues. Animal studies suggest excessive NAD+ could promote cancer growth in immunocompromised mice. But human research supports its protective role in cognitive health, inflammation reduction, and immune function, with no evidence suggesting lasting side effects. Also, cells rapidly clear excess NAD+ from the blood to maintain balance.”

Final Verdict

AgelessRx makes it easier than ever to access a science-backed longevity treatment like NAD+. Whether you’re looking to improve energy, cognitive function, or overall wellness, NAD+ supplementation offers an effective, research-supported solution. AgelessRx’s holistic approach to health addresses your unique needs and goals, providing accessible, personalized treatments designed with your longevity in mind. AgelessRx NAD+ has changed my life for the better. I highly recommend it to anyone wanting to take control of their health and aging.

If you’re ready to explore the benefits of NAD+, AgelessRx can help you feel your best for years to come.